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Wilms-Tumor, Nephroblastom |
Allgemeines |
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Epidemiologie |
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Wilms |
Nephroblastom, Wilms-Tumor. WT1:
Wilms-Tumor-Gen, Schlüsselrolle bei der Entwicklung der Niere. Fehlfunktion im
Kindesalter führt zum Nephroblastom. |
Genetik |
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Klinik |
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Metastasierung |
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Staging |
NWTS-3-Staging Stage I Tumor confined
to the kidney and completely resected; no penetration of the renal capsule or
involvement of renal sinus vessels Stage II Tumor extends beyond the kidney but
is completely resected (negative margins and lymph nodes); at least one of the
following has occurred: Penetration of the renal capsule Invasion of the renal
sinus vessels Biopsy of the tumor before removal Spillage of tumor locally
during removal Stage III Gross or microscopic residual tumor remains
postoperatively including: Positive surgical margins Tumor spill involving
peritoneal surface Regional lymph node metastases Transected vena caval tumor
thrombus Stage IV Hematogenous metastases or lymph node metastases outside the
abdomen Stage V Bilateral renal Wilms tumors
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Diagnostik |
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Morphologie |
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Therapie |
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Operation |
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Radiatio |
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Chemotherapie |
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Zytokintherapie |
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Targettherapie |
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offene Protokolle |
Ergebnisse |
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Quellen |
1.) Mitchell C, Pritchard-Jones K, Shannon R, et al.:
Immediate nephrectomy versus preoperative chemotherapy in the management of
non-metastatic Wilms’ tumour: Results of a randomised trial (UKW3) by the UK
Children’s Cancer Study Group.
Eur J Cancer 42(2006):2554–2562
2.) de Kraker J, Graf N, van Tinteren H, et al.:
Reduction of postoperative chemotherapy in children with stage I intermediate
risk and anaplastic Wilms’ tumour (SIOP 93-01 trial): A randomised controlled
trial.
Lancet 364(2004):1229–1235.
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