zurück Home | Tumortherapie: Interleukin | ||||
IL-2 | Denileukin diftitox | Z.Z. Phase III-Prüfung bei cutanen T-Zellymphomen | |||
Aldesleukin, Proleukin® | Synthetisches IL-2-Analogon, Anwendung beim Nierenzellkarzinom und malignen Melanom | ||||
IL-6 | Siltuximab | Testung bei Castleman's disase | |||
Tocilizumab, RoActemra® | |||||
IL-10 | IL-10 reguliert die MHC Klasse II Antigene und das Wachstum von T-Zellen | Ein erhöhtes IL-10 kann die T-Zell-vermittelte Tumor-Abstoßung erhöhen | pegilodecakin, PEG-hIL-10, pegyliertes, humanes IL-10 | rejection. 15 Preclinical experience with pegylated recombinant murine IL-10 (PEG-rMuIL-10) led to ex- pansion of tumor-speci fi c intratumoral CD8 1 T-cells in mice and directly enhanced the cytotoxic activity of CD8 1 T-cells in vitro. 16 Early trials with a PEGylated recombinant IL-10 termed () in patients with advanced solid tumors demonstrated signs of antitumor activity, with PEG monotherapy providing lasting partial responses in 27% of these heavily pretreated patients with renal cell carcinoma (RCC). 17 In phase I study IVY, PEG revealed a tolerable safety pro fi le with single-agent activity in RCC and uveal melanoma. 18 A | |
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Immunmodulatoren | immunologische Therapie | Therapie von Tumorerkrankungen | Onkologie | |
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Impressum Zuletzt geändert am 10.05.2022 17:52